In order to study the cause of ALS outside of the motoneuron and the nervous system in ALS, we have launched a new study on genetic environmental epidemiology. We believe that interactions between genetic predisposition and environmental/behavioral factors and exposures may lead to oxidative stress in patients who develop ALS. In collaboration with Drs. Ottman and Factor Litvak, we have already developed the interview tools for genetic, behavioral and environmental factors. Now, we are conducting a small center-based study in preparation for a future larger population-based study. For genetic factors, we also have been working with Dr. Kottmann, who is investigating motor neuron specific gene expression, and we are also a part of the ALS DNA repository.
Dr. Hiroshi Mitsumoto is the Wesley J. Howe Professor of Neurology at Columbia University at Columbia Presbyterian Medical Center and is Head of the Neuromuscular Division within the Department of Neurology. Previously he was on the faculty of the Cleveland Clinic Foundation where he served as Director of the ALS Center.
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